A crash near Exit 43 on the Long Island Expressway forced the closure of all eastbound lanes on Saturday morning.
The collision occurred around 2:30 a.m. between a box truck and a smaller vehicle.
Police did not say how many passengers were involved, but the smaller car was left mangled by the crash.
The occupants were taken to area hospitals, but there was no word on their condition as of Saturday morning.
Authorities say the incident is under investigation.