Suffolk police are asking for help in finding 62-year-old Camilla Musolino, of Shirley.
They say she was last seen Tuesday morning driving away in her 2007 gray Toyota Prius.
Detectives say her E-ZPass was last used by the Delaware Water Gap on Tuesday around 1 p.m.
They say Musolino "suffers from diabetes and schizophrenia and may be in need of medical attention."
Musolino is 5 feet 7 inches tall and about 200 pounds. She was last seen wearing blue jeans and a black tank top.
Anyone with information is asked to call Suffolk police at (631) 852-8752.