Taxing Long Island
News12 New York
Download the App
Where to Watch
Local
Crime
Weather
beWell
The East End
Crime Files
Stony Brook Medicine

Understanding ketamine and the death of Matthew Perry

The drug targets a key chemical in the brain, which causes people to feel disconnected from themselves and their feelings.

Gillian Neff

and

Rose Shannon

Dec 17, 2023, 9:51 AM

Updated

Share:

More Stories

"Friends" actor Matthew Perry's autopsy report says his cause of death was acute effects of ketamine.

The drug targets a key chemical in the brain, which causes people to feel disconnected from themselves and their feelings. It has a history of being used in anesthesia for animals and people. It is also known for being as hallucinogenic drug.

In 2019, a version of the drug, esketamine, was approved by the Food and Drug Administration to treat depression along with an anti-depressant.

Although published reports say Perry recently underwent a medically supervised ketamine treatment, doctors say to have a severe and sudden amount of the drug in his system suggests Perry took the drug without medical supervision shortly being getting into a pool.

The autopsy showed the overdose slowed down Perry's breathing. That combination with coronary artery disease and medication he was on for opioid use disorder caused him to accidentally drown.

The Substance Abuse and Mental Health Services Administration can assist people would like help for their addiction. It's a free help line that can be reached 24/7 and is completely confidential.

More Stories

More From News12

App StoreGoogle Play Store

info

Newsletter

Send Photos/Videos

Contact

About Us

News Team

News 12 New York

follow us

Twitter

Facebook

Instagram

more resources

Optimum Corporate

Optimum Service

Advertise on News 12

Careers

Content Removal Policy

© 2026 N12N, LLC

Privacy Policy

Terms of Service

Ad Choices