RIDGE - More than 100 fire departments are responding to a massive brush fire in the Manorville/Ridge area that originated northeast of Brookhaven National Laboratory. Fire officials say approximately 2,000 acres of woods and vegetation are burned or are still burning. As of 11 p.m., Suffolk officials say the fire is not fully contained and warn that unpredictable winds could quickly spread the flames.According to Brookhaven lab officials, the fire started at around 2:30 p.m. near the intersection of William Floyd Parkway and Middle Country Road. Three firefighters were injured battling the flames and were taken to Stony Brook University Medical Center. One suffered burns and two were treated for smoke inhalation, according to Suffolk Executive Steve Bellone.Bellone says one commercial building was completely destroyed by the flames. At least 10 homes were damaged or destroyed, according to the Suffolk County website.Several homes in Manorville were evacuated. The Red Cross has opened a shelter at the Riverhead Senior Center, located at 60 Shade Tree Lane in Aquebogue. As of 12 a.m. Tuesday, Suffolk emergency officials said it was still unsafe for evacuated residents to return to their homes.Bellone says if additional homes are at risk, the county will activate its emergency phone alert system, CodeRED, to advise residents to evacuate. He says firefighters will also go door-to-door to evacuate residents, if needed.Firefighters were pulled back as night began to fall and will continue fighting the fire in the morning, Bellone says. Air National Guard troops stand at the ready to assist if necessary.The Long Island Rail Road says buses will replaces trains between Ronkonkoma and Greenport during the morning rush Tuesday because of the fires.

The National Weather Service had issued a red-flag warning for brush fires for Nassau and Suffolk counties today, signifying a heightened risk of fire.Watch News 12 LIVESuffolk County Evacuation Information